{"id":18541,"date":"2001-06-17T08:40:31","date_gmt":"2001-06-17T11:40:31","guid":{"rendered":"http:\/\/revistapesquisaclone.fapesp.br\/2006\/08\/17\/and-here-come-the-doctors\/"},"modified":"2016-02-11T15:36:40","modified_gmt":"2016-02-11T17:36:40","slug":"and-here-come-the-doctors","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/and-here-come-the-doctors\/","title":{"rendered":"And here come the doctors…"},"content":{"rendered":"
\"\"

M.A. ZAGO Archive\/FMRP-USP<\/span>Genes of chronic myeloid leukemiaM.A. ZAGO Archive\/FMRP-USP<\/span><\/p><\/div>\n

Under the coordination of oncologists and surgeons from S\u00e3o Paulo, eighteen work groups have affiliated themselves to the Clinical Cancer Genome Program, implemented by FAPESP and the Ludwig Institute for Research into Cancer, to analyze the development of genes expressed in four kinds in which cancer manifests itself: lympho-proliferative diseases, gastrointestinal tumors, neurological tumors, and those of the head and neck. The Foundation and the Institute will be putting at the disposal of the groups, for a period of two years, US$ 1 million for financing equipment and the personnel directly involved in collecting the patients’ material and clinical data.<\/p>\n

Each kind of tumor will be analyzed by at least six groups of general practitioners and surgeons. In their research, they will be able to count on the support of another four groups, made up of pathologists who will be responsible for making the criteria for diagnoses homogeneous and for classifying the tumors, among other activities, and by epidemiologists who will help with the planning of the projects, such as for example – defining the number of patients in the sample and the vital statistics. “Each one of the coordinators is connected to big clinics or hospitals with their own criteria for diagnostics, classification of diseases, etc. The program will need to unify all of this in order to reach common results”, explains Marco Antonio Zago, the coordinator of the program.<\/p>\n

On June 11th last, the groups met for the first time, to define the types of tumor whose development they will be monitoring. The second step will be to begin to collect the biological material and to start the clinical observations. The expectation is that the groups will already have sufficient material to begin their analyses from the sixth month of the program. “The material collected will be examined by laboratories that are to be defined”, states Zago. The laboratories are going to analyze the genomic expression of each tumor and compare it with the development of normal cells.<\/p>\n

“For the first approach, the clones of the Cancer Genome will be used.” The strategy for research is to associate the biological material with the background of the patient, the kind of tumor, the response to treatment and the evolution of the disease. “And this is critical for getting some kind of organized information”, says Zago.Before the material starts to be collected, the coordinators will have to ask for authorization from the committees of ethics of their respective hospitals, and to produce, under the supervision of the committee of ethics, an explanation that will be shown to the patient.<\/p>\n

One of the main targets of the Clinical Genome Program is to transfer the success of the basic projects of the Cancer Genome to the applied part, according to Zago. Another pertinent point is that the program sets out to create a model of organization of research, based on cooperative groups, with specific targets. “If it works out, this model may be valid for other related medical themes, like diabetes, for example.”<\/p>\n

Coordinators<\/strong>\u00a0\/Institutions<\/strong><\/p>\n

Alberto Alain Gabbai \/ Unifesp
\nAngelita Habr-Gama \/ USP
\nAntonio Sergio Petrilli \/ Unifesp
\nCarlos Eduardo Bacchi \/ Unesp
\nCarlos Gilberto Carlotti Jr. \/ USP-RP
\nDelcio Matos \/ Unifesp
\nFrancisco Gorgonio da N\u00f3brega \/ Univap
\nGisele Wally Braga Colleoni \/ Unifesp
\nIvan Cecconello \/ USP
\nJoaquim Jos\u00e9 Gama-Rodrigues \/ USP
\nJos\u00e9 Eluf Neto \/ USP
\nJos\u00e9 Francisco de Gois Filho \/ IC Arnaldo Vieira de Carvalho
\nKiyoshi Iriya \/ USP
\nLuiz Gonzaga Tone \/ USP-RP
\nMarcello Fabiano de Franco \/ USP
\nMarcos Brasilino de Carvalho \/ Heli\u00f3polis Hospital
\nMaria Lucia de Martino Lee \/ Unifesp
\nNora Manoukian Forones \/ Unifesp
\nPatricia Maluf Cury \/ FMSJRP
\nPaulo Andrade Lotufo \/ USP
\nPedro Michaluart Junior \/ USP
\nRaul Cutait \/ S\u00edrio Liban\u00eas Hospital
\nSergio Rosemberg \/ USP
\nSilvia Regina Brandalise \/ Boldrini Center for Infants
\nSuely Kazue Nagahashi Marie \/ USP
\nVen\u00e2ncio Avancini Ferreira Alves \/ USP
\nVera Luiza Capelozzi \/ USP
\nVicente Odone Filho \/ USP
\nVictor W\u00fcnsch Filho \/ USP<\/p>\n","protected":false},"excerpt":{"rendered":"FAPESP publishes list of groups affiliated to the Clinical Genome Program","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[166],"tags":[],"coauthors":[93],"class_list":["post-18541","post","type-post","status-publish","format-standard","hentry","category-policies-st-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/18541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=18541"}],"version-history":[{"count":0,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/18541\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=18541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=18541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=18541"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=18541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}