{"id":225394,"date":"2016-10-04T12:24:13","date_gmt":"2016-10-04T15:24:13","guid":{"rendered":"http:\/\/revistapesquisa.fapesp.br\/en\/?p=225394"},"modified":"2016-10-04T12:24:13","modified_gmt":"2016-10-04T15:24:13","slug":"to-observe-chemical-reactions","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/to-observe-chemical-reactions\/","title":{"rendered":"To observe chemical reactions"},"content":{"rendered":"<div id=\"attachment_225395\" style=\"max-width: 310px\" class=\"wp-caption alignright\"><a href=\"http:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2016\/09\/Tecno_redox.jpg\" rel=\"attachment wp-att-225395\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-225395\" src=\"http:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2016\/09\/Tecno_redox-300x266.jpg\" alt=\"A map of chemical reactions: yellow and red spots (inset) indicate mouse embryo tissues where more H2O2 is being produced\" width=\"300\" height=\"266\" \/><p class=\"wp-caption-text\"><span class=\"media-credits-inline\">Let\u00edcia Roma \/ DKFZ<\/span><\/a> A map of chemical reactions: yellow and red spots (<em>inset<\/em>) indicate mouse embryo tissues where more H<sub>2<\/sub>O<sub>2<\/sub> is being produced<span class=\"media-credits\">Let\u00edcia Roma \/ DKFZ<\/span><\/p><\/div>\n<p>A team from the German Cancer Research Center (DKFZ) has developed a strategy to make it possible to observe the evolution of certain chemical reactions\u2014and quantify the results\u2014in tissues of relatively large organisms. So far, this experimental strategy has been used in mice\u2014animal models for the study of health problems in humans. Previously, it was only possible to observe the development of these chemical reactions in translucent organisms with few tissue layers, such as embryos of both fish and fruit flies. The group from DKFZ, including Brazilian researcher Let\u00edcia Roma, created rodents that were genetically altered to produce a phosphorescent protein sensitive to levels of oxygenated water (H<sub>2<\/sub>O<sub>2<\/sub>). These molecules are generated by a cell organelle\u2014mitochondria\u2014during the conversion of nutrients to energy. In small quantities, the molecule functions as an internal communicator; at high levels, it causes internal damage to the cell or even death. Scientists suspect that excessive production is responsible for an organism\u2019s aging and the development of degenerative diseases. Using this strategy, which involves cryopreservation of the tissue and a chemical bath, the researchers measured the production of H<sub>2<\/sub>O<sub>2<\/sub> during tumor development and an inflammatory reaction (<em>Science Signaling<\/em>, March 15, 2016). According to Roma, the group expects to use the technique to see whether alterations in the production of H<sub>2<\/sub>O<sub>2<\/sub> are linked to diabetes.<\/p>\n","protected":false},"excerpt":{"rendered":"Strategy makes it possible to observe chemical reactions in the organism","protected":false},"author":475,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[168],"tags":[211,210,259],"coauthors":[785],"class_list":["post-225394","post","type-post","status-publish","format-standard","hentry","category-technoscience","tag-biochemistry","tag-cellular-biology","tag-chemistry"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/225394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=225394"}],"version-history":[{"count":0,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/225394\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=225394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=225394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=225394"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=225394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}