{"id":229511,"date":"2017-01-06T15:06:48","date_gmt":"2017-01-06T17:06:48","guid":{"rendered":"http:\/\/revistapesquisa.fapesp.br\/en\/?p=229511"},"modified":"2017-01-06T15:06:48","modified_gmt":"2017-01-06T17:06:48","slug":"innovative-vision-of-pharmacology","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/innovative-vision-of-pharmacology\/","title":{"rendered":"Innovative vision of pharmacology"},"content":{"rendered":"
\"Ferreira:

Matuiti Mayezo \/ Folhapress <\/span>Ferreira: always concerned about the mechanisms of action of drugs and about Brazilian scienceMatuiti Mayezo \/ Folhapress <\/span><\/p><\/div>\n

In November 2010, at age 76, pharmacologist S\u00e9rgio Henrique Ferreira expressed his gratitude to fellow pharmacologist Maur\u00edcio Rocha e Silva, his doctoral adviser at the Ribeir\u00e3o Preto School of Medicine (FMRP) of the University of S\u00e3o Paulo (USP). \u201cIt was Rocha e Silva who taught me to look at things carefully,\u201d he said during a break at a conference in Rio de Janeiro. Ferreira, age 81, died July 17, 2016 in Ribeir\u00e3o Preto.<\/p>\n

A native of the S\u00e3o Paulo city of Franca and graduate of the USP School of Medicine, Ferreira, at 31, isolated the peptides of jararaca<\/i><\/em> venom that are capable of inhibiting an enzyme that degrades bradykinin, a hormone that reduces blood pressure. Ferreira wrote an article describing his discovery and included the name of his advisor, Rocha e Silva, who had discovered bradykinin, thinking he would co-sign it. Rocha e Silva crossed off his own name: \u201cIf I go in on it, no one will believe that you did it yourself.\u201d<\/p>\n

Discovery of the so-called Bradykinin Potentiating Factor prompted the US company Bristol-Myers Squibb to develop a new class of drugs against high blood pressure, released as Captopril. \u201cS\u00e9rgio was perhaps the only Brazilian whose experiments, carried out completely in Brazil, enabled the creation of a class of drugs,\u201d says pharmacologist Fernando Cunha, who moved from Rio de Janeiro to pursue a doctoral degree with Ferreira in 1983 before being hired as professor at FMRP four years later.<\/p>\n

Ferreira lived in England with his wife Maria Clotilde Rossetti Ferreira and three children on two different occasions. From 1964 to 1967 and from 1970 to 1973 he did post-doctoral research stints at the Royal College of Surgeons of England with pharmacologist John Vane, who was later awarded the Nobel Prize in Physiology or <\/u>Medicine in 1982. During his second stint with Vane, he studied the mechanism of action of acetylsalicylic acid (Aspirin), which, as he noted, inhibits the synthesis of prostaglandins, the molecules that reduce the sensitivity of neurons associated with pain.\u00a0 From 1974 to 1975, he worked at Wellcome Research, an institution associated with the pharmaceutical company Wellcome Laboratories.<\/p>\n

Resourceful and demanding<\/b><\/strong>
\nIn other research, Ferreira determined that morphine, in addition to its effects on the central nervous system, also has a peripheral analgesic effect, which he called teleantagonism (see Pesquisa FAPESP<\/i><\/em> Issue n\u00ba 155<\/a>). \u201cAs professor and researcher at the FMRP, he was quite resourceful and demanding with regard to the quality of work by the team,\u201d says Janetti Nogueira de Francischi, professor at the Institute of Biological Sciences of the Federal University of Minas Gerais (ICB-UFMG) who worked with him from 1977 to 1985, while pursuing her master\u2019s and doctoral degrees. \u00a0\u201cHe always encouraged\u00a0us to keep moving forward.\u201d<\/p>\n

Ferreira was actively involved in science policy discussions in Brazil, mainly while serving as president of the SBPC for two terms from 1995 to 1999. \u201cFifty years ago, we were thinking about establishing FAPESP, CNPq and graduate studies, institutions that are now going strong.\u00a0 What\u2019s our strategy for the next 50 years?\u201d he asked in 2010, concerned as always about the course of Brazilian science.<\/p>\n","protected":false},"excerpt":{"rendered":"S\u00e9rgio Henrique Ferreira researched medications to fight hypertension and pain","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[159],"tags":[247,232],"coauthors":[5968],"class_list":["post-229511","post","type-post","status-publish","format-standard","hentry","category-science","tag-medicine","tag-pharmacology"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/229511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=229511"}],"version-history":[{"count":0,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/229511\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=229511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=229511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=229511"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=229511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}