{"id":246945,"date":"2017-10-09T14:56:32","date_gmt":"2017-10-09T17:56:32","guid":{"rendered":"http:\/\/revistapesquisa.fapesp.br\/?p=246945\/"},"modified":"2017-10-10T18:19:43","modified_gmt":"2017-10-10T21:19:43","slug":"three-dimensional-model-against-zika","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/three-dimensional-model-against-zika\/","title":{"rendered":"Three-dimensional model against Zika"},"content":{"rendered":"<div id=\"attachment_246947\" style=\"max-width: 310px\" class=\"wp-caption alignright\"><a href=\"http:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2017\/10\/012_notas08_254.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-246947\" src=\"http:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2017\/10\/012_notas08_254-300x294.jpg\" alt=\"\" width=\"300\" height=\"294\" \/><p class=\"wp-caption-text\"><span class=\"media-credits-inline\">ANDR\u00c9 GODOY \/ USP<\/span><\/a> The three-dimensional structure of the NS5 protein has been likened to a hand, with a palm, thumb, and three fingers<span class=\"media-credits\">ANDR\u00c9 GODOY \/ USP<\/span><\/p><\/div>\n<p>In the fight against the Zika virus, many research groups are studying NS5, the protein produced by the virus and primarily responsible for its replication once it has infected the cells. A group led by Glaucius Oliva, a physicist from the S\u00e3o Carlos Institute of Physics at the University of S\u00e3o Paulo (IFSC-USP) and coordinator at the Center for Research and Innovation in Biodiversity and Drug Discovery (CIBFAR), was able to produce crystals of the protein, revealing the three-dimensional structure of the molecule and the thousands of atoms that compose it with high precision (<em>Nature Communications<\/em>, March 27). With this structure identified, the researchers expect a race to discover how to prevent the protein from functioning and to produce a drug that could halt the disease after a mosquito bite or as soon as symptoms appear, or at least accelerate recovery and reduce damage. &#8220;We seek to develop drugs by modeling the molecules that interact with specific receptors,&#8221; says Oliva. CIBFAR is one of the centers that comprise the Research, Innovation, and Dissemination Centers (RIDC) funded by FAPESP.<\/p>\n","protected":false},"excerpt":{"rendered":"Protein structure essential to zika virus replication is unraveled\r\n","protected":false},"author":475,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1651],"tags":[211,259,232,235],"coauthors":[785],"class_list":["post-246945","post","type-post","status-publish","format-standard","hentry","category-notes","tag-biochemistry","tag-chemistry","tag-pharmacology","tag-physics"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/246945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=246945"}],"version-history":[{"count":0,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/246945\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=246945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=246945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=246945"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=246945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}