There are still problems. “In Brazil there is a shortage of donors and medical centers that can conduct transplants,” says cardiologist Roberto Kalil Filho, director-general of INCOR. Medical centers in only four states (S\u00e3o Paulo, Minas Gerais, Pernambuco and the Federal District) perform more than 30 of these surgeries per year.<\/p>\n In addition to complex logistics, one of the factors limiting the number of organ donors (which includes but is not limited to hearts) is the high rate of family refusal, which according to the ABTO was 44% in 2015. One reason could be that medical teams are not prepared to explain the concept of brain death to families, according to a 2015 study at the Federal University of S\u00e3o Paulo (see<\/em> Pesquisa FAPESP issue no. 237<\/em><\/a>). Other barriers include failures in identification of and notification about potential donors, medical contraindications, and transport difficulties between hospitals.<\/p>\n The first three transplants were performed in 1968 and 1969 at the Hospital das Cl\u00ednicas (HC) at the USP School of Medicine, and served to broaden training and recognition among medical professionals, institutions, and companies. “INCOR is the product of Jo\u00e3o Boiadeiro,” says 80-year-old heart surgeon Domingo Marcolino Braile, referring to Jo\u00e3o Ferreira da Cunha, the 23-year-old who was the first Brazilian and seventeenth person in the world to receive a new heart.<\/p>\n His surgery took place five months after the South African surgeon Christiaan Barnard (1922\u20132001) performed the world\u2019s first heart transplant in a hospital at the University of Cape Town, South Africa, on December 3, 1967, applying techniques learned alongside the American surgeon Norman Edward Shumway (1923\u20132006) at Stanford University in the United States. Barnard\u2019s patient, Louis Washkanski (who today would be an unlikely candidate for this procedure because of high blood pressure in the lung arteries) lived for 18 days after surgery. Even so, the first transplant had immediate international repercussions.<\/p>\n HC-USP Publicity \/ Reproduction Eduardo Cesar <\/span><\/a> Medical team observes patient undergoing the first heart transplant in Brazil, conducted at the USP Hospital das Cl\u00ednicas in 1968HC-USP Publicity \/ Reproduction Eduardo Cesar <\/span><\/p><\/div>\n Jo\u00e3o Boaideiro\u2019s transplant also had a large impact in Brazil, the sixth country to perform this type of operation after South Africa, the United States, India, France, and the United Kingdom. The surgeon Euryclides de Jesus Zerbini (1912\u20131993) led the team that conducted the procedure on the morning of May 26, 1968, at the Hospital das Cl\u00ednicas at USP. “Zerbini fought for INCOR for at least 10 years, but it did not get off the drawing board,” wrote surgeon Euclydes Marques, Zerbini\u2019s assistant, in his 1960 book A face oculta dos transplantes <\/em>(The hidden face of transplants<\/em>). Soon after the transplant, funding to build INCOR was released. Construction on the building began shortly thereafter, and the institute was opened in 1975.<\/p>\n The transplant, unfortunately, did not go so well. Eighteen days after the surgery, Jo\u00e3o Boiadeiro began to show signs that his body was rejecting the heart he had received. The rejection worsened, the heart stopped working, and the young man from Mato Grosso nicknamed Jo\u00e3o the Cowboy died 28 days after surgery. In September of 1968 the INCOR team performed its second transplant on Hugo Orlandi, a 48-year-old from S\u00e3o Paulo, who died 378 days later, also after rejection of the heart. “At that time, the arsenal of medications to combat rejection was rather limited,” says Bacal. The third transplant patient, Clarismundo Pra\u00e7a, a 52-year-old man from S\u00e3o Paulo, did not reject the heart, but died 83 days after surgery was performed in January 1969 from a generalized infection which began in the surgical incision.<\/p>\n Because of the difficulty controlling rejection, which translated into low survival rates for the people who received transplants, this procedure practically ceased around the world until the 1980s. What allowed transplants to resume was the discovery of cyclosporin, a compound isolated from a fungus by the Swiss biochemist Jean-Francois Borel which proved to be a powerful immunosuppressant capable of reducing the reactions that cause rejection of transplanted organs. Cyclosporin was soon adopted in transplants along with corticosteroids and azathioprine, which had been used up until this point. INCOR resumed transplants in 1985, one year after the surgeon Ivo Nesralla performed one at the Cardiology Institute of Rio Grande do Sul, the first Brazilian surgery of this kind in the post-cyclosporin era. From then on, the number of heart transplants began to climb continuously (see chart<\/em><\/a>).<\/p>\n Transplants in dogs<\/strong> L\u00e9o Ramos Chaves<\/span><\/a> Cardiopulmonary bypass machine used in heart surgeries in the 1950s and 1960sL\u00e9o Ramos Chaves<\/span><\/p><\/div>\n In his book, Marques says that he had found a candidate who appeared to be suitable for transplant in 1967: a 36-year-old woman with a tumor in the heart called a rhabdomyosarcoma. He proposed the surgery in a meeting with other physicians, and Luiz Venere D\u00e9court (1911\u20132007) asked how many dogs had survived the transplant. Marques had to acknowledge: none. The following year, Christiaan Barnard (who was already famous) answered the same question from D\u00e9court on a visit to INCOR, saying that none of the dogs he had operated on had survived. F\u00e1bio Jatene commented: “The dog was a model used to practice the surgical technique, although the animal does not survive to the end. It has been years since we used dogs for this purpose.”<\/p>\n Since the 1950s, the team that would comprise INCOR strengthened the research and development of equipment and devices used in cardiac surgery. To foster this area, Zerbini brought his ex-student Adib Jatene (1929\u20132014), a surgeon in Uberaba, Minas Gerais at the time who was recognized for his medical competence as well as his ability to build machines, back to the Hospital das Cl\u00ednicas with him. In 1958, Jatene and Braile, who was in his second year of medical school, built the cardiopulmonary bypass machine, which functioned as a mechanical lung and heart to keep blood circulating during surgery and was used in cardiac procedures and in the first transplants (see<\/em> Pesquisa FAPESP issue no. 154<\/em><\/a>). Zerbini had imported one of these machines, but replacement parts were hard to obtain. He also encouraged the team from the hospital workshop to produce blood flow control valves, since imported valves were very expensive. This desire for autonomy remains; the Bioengineering Division is located two stories underground and produces devices including valves, catheters, and pacemaker chips, as well as an experimental artificial ventricle used as a temporary heart in people awaiting a transplant.<\/p>\n In 1961, Jatene moved to the Dante Pazzanese Institute, where he created the bioengineering workshop to develop instruments and devices. There he created the first pacemaker, which did not advance because of difficulties obtaining electronic components. In 1983 he returned to INCOR to fill the full professor spot left by Zerbini, who had just retired. After Braile graduated in 1962, he returned to his home town of S\u00e3o Jos\u00e9 do Rio Preto in the interior of S\u00e3o Paulo, formed cardiac surgery teams, and in 1983 created his own company, which produces heart valves and other devices for cardiology and oncology (see<\/em> Pesquisa FAPESP issue no. 176<\/em><\/a>). “Zerbini was very modest and said he was proud that his students had gone farther than he did,” recalls Braile.<\/p>\n Scientific articles<\/strong> Book<\/strong>![\"\"](\"http:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2018\/08\/064-067_Transplante-cora\u00e7\u00e3o_266.jpg\"){kind=spacer}
<\/a><\/p>\n
\nEuclydes Marques, who today is 82 years old, recalls being part of the team that prepared to conduct the first heart transplants in humans. He led a group of medical students who performed more than 100 transplants in dogs in 1967 and 1968. “Zerbini supported it, but not directly, because he did not believe in the viability of the transplant at that time,” says Marques. “If he had believed in it, he would have taken action before.” It was only when he learned of the first transplant in South Africa, according to Marques, that the surgeon became interested in the canine transplants, and did some in animals and then others in cadavers until he felt secure.<\/p>\n
\nD\u00c9COURT, L. V. e ZERBINI, E. J. Transplante de cora\u00e7\u00e3o humano: Considera\u00e7\u00f5es sobre tr\u00eas casos. Revista do Hospital das Cl\u00ednicas da Faculdade de Medicina de S\u00e3o Paulo<\/strong>. Vol. 25, no. 4, pp. 207\u201326. July\u2013Aug. 1970.
\nGOMES, W. J. et al.<\/em> The Brazilian registry of adult patient undergoing cardiovascular surgery, the BYPASS Project: Results of the first 1,722 patients.<\/a> Revista Brasileira de Cirurgia Cardiovascular<\/strong>. Vol. 32, no. 2, pp. 71\u20135. Mar.\u2013Apr. 2017.<\/p>\n
\nMARQUES, E. A face oculta dos transplantes<\/strong>. S\u00e3o Paulo: Holos, 2012.<\/p>\n","protected":false},"excerpt":{"rendered":"Fifty years after the first heart transplant, survival is up but donors remain scarce","protected":false},"author":17,"featured_media":260973,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[159],"tags":[247],"coauthors":[5968],"class_list":["post-260969","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-medicine"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/260969","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=260969"}],"version-history":[{"count":0,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/260969\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media\/260973"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=260969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=260969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=260969"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=260969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}