{"id":375518,"date":"2021-01-26T15:26:44","date_gmt":"2021-01-26T18:26:44","guid":{"rendered":"https:\/\/revistapesquisa.fapesp.br\/?p=375518"},"modified":"2021-01-26T15:26:44","modified_gmt":"2021-01-26T18:26:44","slug":"lasting-action-against-hiv","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/lasting-action-against-hiv\/","title":{"rendered":"Lasting action against HIV"},"content":{"rendered":"<div id=\"attachment_375614\" style=\"max-width: 810px\" class=\"wp-caption alignright\"><a href=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2021\/01\/012-017_Notas_294-6-1140.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-375614 size-full\" src=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2021\/01\/012-017_Notas_294-6-1140.jpg\" alt=\"\" width=\"800\" height=\"1132\" srcset=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2021\/01\/012-017_Notas_294-6-1140.jpg 800w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2021\/01\/012-017_Notas_294-6-1140-250x354.jpg 250w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2021\/01\/012-017_Notas_294-6-1140-700x991.jpg 700w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2021\/01\/012-017_Notas_294-6-1140-120x170.jpg 120w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><p class=\"wp-caption-text\"><span class=\"media-credits-inline\">Random 42<\/span><\/a> Illustration showing the destruction (<em>purpura<\/em>) of a virus capsid<span class=\"media-credits\">Random 42<\/span><\/p><\/div>\n<p>Researchers at American pharmaceutical company Gilead Sciences have published the results of clinical trials of a new long-acting antiretroviral against HIV (<em>Nature<\/em>, July 1). The GS-6207 molecule (lenacapavir) inhibits assembly and disassembly of the capsid, the structure that contains the viral RNA. A test of 40 healthy individuals who received a dose by subcutaneous injection indicated that the compound is safe, well tolerated, and remains active in the body for more than six months. Another trial, this time involving 32 HIV-positive patients, showed a reduction in viral load nine days after receiving a dose of lenacapavir. Virologist Sumit Chanda of the Sanford Burnham Prebys Medical Discovery Institute in the USA, who did not participate in the study, told news website <em>Stat<\/em> that there is concern about future resistance to the drug. According to Gilead, lenacapavir should be used in combination with other antiretrovirals.<\/p>\n","protected":false},"excerpt":{"rendered":"Researchers at American pharmaceutical company Gilead Sciences have published the results of clinical trials of a new long-acting antiretroviral against HIV","protected":false},"author":475,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1651],"tags":[247,232],"coauthors":[785],"class_list":["post-375518","post","type-post","status-publish","format-standard","hentry","category-notes","tag-medicine","tag-pharmacology","keywords-virology"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/375518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=375518"}],"version-history":[{"count":3,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/375518\/revisions"}],"predecessor-version":[{"id":376112,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/375518\/revisions\/376112"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=375518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=375518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=375518"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=375518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}