{"id":381043,"date":"2021-02-15T14:59:24","date_gmt":"2021-02-15T17:59:24","guid":{"rendered":"https:\/\/revistapesquisa.fapesp.br\/?p=381043"},"modified":"2021-02-15T14:59:24","modified_gmt":"2021-02-15T17:59:24","slug":"mutation-makes-covid-19-less-serious","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/mutation-makes-covid-19-less-serious\/","title":{"rendered":"Mutation makes COVID-19 less serious"},"content":{"rendered":"<p>A mutation that erased a stretch of DNA from two SARS-CoV-2 genes appears to make the symptoms of COVID-19 less aggressive. A team led by molecular biologist Lisa Ng of the Singapore Immunology Network monitored the progress of the disease in 29 patients who had contracted a version of the coronavirus with the genetic alteration, observing that none of them needed to receive supplemental oxygen (<em>Lancet<\/em>, August 18). In another group of 92 COVID-19 patients infected by a strain of the pathogen without the mutation, 26 individuals had to use artificial respirators. SARS-CoV-2 variants with the genetic alteration were circulating in Asia at the beginning of the pandemic, but the mutation, which affects the ORF8 and ORF7b genes<em>, <\/em>has not been identified since March. During the Severe Acute Respiratory Syndrome (SARS) outbreak in the early 2000s, the virus that causes the disease also had a mutation in the ORF8 gene.<\/p>\n","protected":false},"excerpt":{"rendered":"A mutation that erased a stretch of DNA from two SARS-CoV-2 genes appears to make the symptoms of COVID-19 less aggressive","protected":false},"author":475,"featured_media":381619,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1651],"tags":[237],"coauthors":[785],"class_list":["post-381043","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notes","tag-genetics","keywords-coronavirus-en","keywords-covid-19-en","keywords-sars-cov-2-en","keywords-virology"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/381043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=381043"}],"version-history":[{"count":2,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/381043\/revisions"}],"predecessor-version":[{"id":381623,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/381043\/revisions\/381623"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media\/381619"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=381043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=381043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=381043"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=381043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}