{"id":405406,"date":"2021-08-20T12:17:31","date_gmt":"2021-08-20T15:17:31","guid":{"rendered":"https:\/\/revistapesquisa.fapesp.br\/?p=405406"},"modified":"2021-08-20T12:17:31","modified_gmt":"2021-08-20T15:17:31","slug":"the-awakening-of-a-dormant-virus","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/the-awakening-of-a-dormant-virus\/","title":{"rendered":"The awakening of a dormant virus"},"content":{"rendered":"<p>The increasing number of COVID-19 cases may in part be due to a phenomenon that has not yet been observed in the pandemic: the activation of a second virus that has previously laid dormant in the human genome. It is not yet fully understood how, but SARS-CoV-2 appears to awaken the human endogenous retrovirus of the K family (HERV-K), which was incorporated into our genome millions of years ago. The result is a more serious infection, which can kill the patient faster (<em>Research Square<\/em>, May 11). Led by biologist Thiago Moreno Lopes e Souza from the Oswaldo Cruz Foundation (FIOCRUZ), a group of researchers from Rio de Janeiro and China analyzed all the viruses (the virome) found in the tracheal secretion of 25 COVID-19 patients on mechanical ventilators. In all of them, they found HERV-K levels at least five times higher than observed in the nasal secretions of people with moderate symptoms of the disease. \u201cThese HERV-K levels correlated with what was called early mortality, when a patient dies after less than 28 days in hospital,\u201d said Lopes e Souza. In human cell cultures, SARS-CoV-2 activated the multiplication of HERV-K in monocytes, a type of immune cell.<\/p>\n","protected":false},"excerpt":{"rendered":"Study suggests that SARS-CoV-2 activates dormant virus in the human genome","protected":false},"author":475,"featured_media":406126,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1651],"tags":[237],"coauthors":[785],"class_list":["post-405406","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notes","tag-genetics","keywords-coronavirus-en","keywords-covid-19-en","keywords-sars-cov-2-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/405406","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=405406"}],"version-history":[{"count":3,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/405406\/revisions"}],"predecessor-version":[{"id":406682,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/405406\/revisions\/406682"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media\/406126"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=405406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=405406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=405406"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=405406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}