{"id":512175,"date":"2024-05-23T11:14:24","date_gmt":"2024-05-23T14:14:24","guid":{"rendered":"https:\/\/revistapesquisa.fapesp.br\/?p=512175"},"modified":"2024-05-23T11:14:24","modified_gmt":"2024-05-23T14:14:24","slug":"reinforcement-against-rabies","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/reinforcement-against-rabies\/","title":{"rendered":"Reinforcement against rabies"},"content":{"rendered":"<div id=\"attachment_512180\" style=\"max-width: 1150px\" class=\"wp-caption alignright vertical\"><a href=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2024\/05\/RPF-notas-raiva-celulas-2023-11-site-1140-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-512180 size-full\" src=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2024\/05\/RPF-notas-raiva-celulas-2023-11-site-1140-1.jpg\" alt=\"\" width=\"1140\" height=\"716\" srcset=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2024\/05\/RPF-notas-raiva-celulas-2023-11-site-1140-1.jpg 1140w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2024\/05\/RPF-notas-raiva-celulas-2023-11-site-1140-1-250x157.jpg 250w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2024\/05\/RPF-notas-raiva-celulas-2023-11-site-1140-1-700x440.jpg 700w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2024\/05\/RPF-notas-raiva-celulas-2023-11-site-1140-1-120x75.jpg 120w\" sizes=\"auto, (max-width: 1140px) 100vw, 1140px\" \/><p class=\"wp-caption-text\"><span class=\"media-credits-inline\">NIAID\u2009\/\u2009Wikimedia Commons<\/span><\/a> Cells in culture (<em>green<\/em>) infected with the rabies virus (<em>red<\/em>)<span class=\"media-credits\">NIAID\u2009\/\u2009Wikimedia Commons<\/span><\/p><\/div>\n<p>Scientists from the University of S\u00e3o Paulo, Brazilian company Orygen, and American company Oncovir evaluated the possible effects of Poly ICLC Hiltonol, a synthetic drug used experimentally to help combat cancer by stimulating the immune system. After application of a solution containing the rabies-causing <em>Lyssavirus<\/em>, nine mice were given a placebo and nine were given a modified form of the compound. All the animals in the control group died within 14 days. The first death in the test group occurred on the 12<sup>th<\/sup> day and the last on the 19<sup>th<\/sup>\u2014despite living longer, all the mice died, indicating that higher dosages might be needed than were used in the experiment (5 micrograms per day). Transmitted by infected dogs, cats, and wild animals and treated with a vaccine or serum, rabies causes around 60,000 deaths per year in 150 countries, the majority in Africa and Asia. In Brazil, the Ministry of Health recorded five deaths in 2022 and two by May of this year. In August, researchers from the Federal University of S\u00e3o Paulo (UNIFESP) reported that they had found variants of the virus found in common marmosets (<em>Callithrix jacchus<\/em>) in bats in Cear\u00e1, suggesting the possibility of transmission between the animals (<em>bioRxiv<\/em>, September 20; <em>Journal of Medical Virology<\/em>, August 22; <em>Ag\u00eancia FAPESP<\/em>, September 21).<\/p>\n","protected":false},"excerpt":{"rendered":"Experimental synthetic drug evaluated as alternative means of fighting the human rabies virus","protected":false},"author":475,"featured_media":496859,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1651],"tags":[232],"coauthors":[785],"class_list":["post-512175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notes","tag-pharmacology"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/512175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=512175"}],"version-history":[{"count":1,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/512175\/revisions"}],"predecessor-version":[{"id":512184,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/512175\/revisions\/512184"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media\/496859"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=512175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=512175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=512175"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=512175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}