{"id":520508,"date":"2024-09-11T08:49:46","date_gmt":"2024-09-11T11:49:46","guid":{"rendered":"https:\/\/revistapesquisa.fapesp.br\/?p=520508"},"modified":"2024-09-11T08:49:46","modified_gmt":"2024-09-11T11:49:46","slug":"signs-of-parkinsons-disease-in-the-skin","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/signs-of-parkinsons-disease-in-the-skin\/","title":{"rendered":"Signs of Parkinson&#8217;s disease in the skin"},"content":{"rendered":"<p>In the future, a simple skin sample test could help doctors diagnose Parkinson&#8217;s disease and three other neurodegenerative diseases marked by a buildup of an altered form of the alpha-synuclein protein in the central nervous system. In a study involving 343 patients aged 40 to 99 treated at 30 medical centers in the USA, neurologist Christopher Gibbons of Harvard Medical School used a chemical marker to identify the altered form of the protein in skin samples. The technique allowed Gibbons to accurately separate people with one of the four diseases \u2014 known together as synucleinopathies \u2014 from people without. The test detected the altered protein in 93% of people diagnosed with Parkinson&#8217;s disease, in 96% of individuals with dementia with Lewy bodies, in 98% of those with multiple system atrophy, and in 100% of individuals with pure autonomic failure. Only 3% of people without a neurological disease tested positive for the altered protein (<em>JAMA<\/em>, March 20). In a previous study with fewer participants, scientists used the test to differentiate Parkinson&#8217;s from multiple system atrophy (<em>Neurology<\/em>, 2023).<\/p>\n","protected":false},"excerpt":{"rendered":"In the future, a skin exam could help doctors diagnose Parkinson&#8217;s disease","protected":false},"author":475,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1651],"tags":[211,210,247],"coauthors":[785],"class_list":["post-520508","post","type-post","status-publish","format-standard","hentry","category-notes","tag-biochemistry","tag-cellular-biology","tag-medicine"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/520508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=520508"}],"version-history":[{"count":1,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/520508\/revisions"}],"predecessor-version":[{"id":520509,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/520508\/revisions\/520509"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=520508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=520508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=520508"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=520508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}