{"id":548403,"date":"2025-06-10T13:56:43","date_gmt":"2025-06-10T16:56:43","guid":{"rendered":"https:\/\/revistapesquisa.fapesp.br\/?p=548403"},"modified":"2025-06-10T13:56:43","modified_gmt":"2025-06-10T16:56:43","slug":"artificial-skin-now-complete","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/artificial-skin-now-complete\/","title":{"rendered":"Artificial skin now complete"},"content":{"rendered":"<div id=\"attachment_548397\" style=\"max-width: 810px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-548397 size-full\" src=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2025\/03\/RPF-notas-pele-artificial-2024-12-800.jpg\" alt=\"\" width=\"800\" height=\"937\" srcset=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2025\/03\/RPF-notas-pele-artificial-2024-12-800.jpg 800w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2025\/03\/RPF-notas-pele-artificial-2024-12-800-250x293.jpg 250w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2025\/03\/RPF-notas-pele-artificial-2024-12-800-700x820.jpg 700w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2025\/03\/RPF-notas-pele-artificial-2024-12-800-120x141.jpg 120w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><p class=\"wp-caption-text\"><span class=\"media-credits-inline\">AVELINO, T. M. <em>et al<\/em>, <strong>Communications Biology<\/strong>, 2024<\/span>Epidermis: functional layers were bioprinted in a laboratory<span class=\"media-credits\">AVELINO, T. M. <em>et al<\/em>, <strong>Communications Biology<\/strong>, 2024<\/span><\/p><\/div>\n<p>Another step has been taken towards replacing animals in the testing of cosmetics and drugs. Researchers from the National Laboratory of Biosciences (LNBio) at the Brazilian Center for Energy and Materials Research (CNPEM) in Campinas have produced an equivalent of complete human skin. Biologist Ana Carolina Figueira and her team used a combination of three human cell types (keratinocytes, fibroblasts, and mesenchymal stem cells). The skin was printed using collagen bioink, which has a liquid consistency at 4 degrees Celsius (\u00b0C) but acquires the consistency of epithelial tissue by incubating at 37 \u00b0C. After being printed, the layers of the skin differentiated, forming the epidermis, with an impermeable surface, and the dermis. The stem cells transformed into adipose cells, which formed the hypodermis. This layer has been shown to be involved in the activation of specific genes for the maintenance of skin physiology, in the proliferation and differentiation of cells, and in skin hydration (<em>Communications Biology<\/em>, November 11).<\/p>\n","protected":false},"excerpt":{"rendered":"Researchers create lab-based equivalent of human skin using human cells and collagen bioink","protected":false},"author":475,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1651],"tags":[212],"coauthors":[785],"class_list":["post-548403","post","type-post","status-publish","format-standard","hentry","category-notes","tag-biotechnology"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/548403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/475"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=548403"}],"version-history":[{"count":1,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/548403\/revisions"}],"predecessor-version":[{"id":548408,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/548403\/revisions\/548408"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=548403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=548403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=548403"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=548403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}