{"id":94040,"date":"2013-01-18T13:13:03","date_gmt":"2013-01-18T15:13:03","guid":{"rendered":"http:\/\/revistapesquisa.fapesp.br\/?p=94040"},"modified":"2013-01-18T13:13:03","modified_gmt":"2013-01-18T15:13:03","slug":"brazilian-collaboration-in-the-nobel-price-in-chemistry","status":"publish","type":"post","link":"https:\/\/revistapesquisa.fapesp.br\/en\/brazilian-collaboration-in-the-nobel-price-in-chemistry\/","title":{"rendered":"Brazilian collaboration in the Nobel Price in Chemistry"},"content":{"rendered":"<div id=\"attachment_94042\" style=\"max-width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-94042\" title=\"\" src=\"http:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2013\/01\/012-013_Estrategias_201-2.jpg\" alt=\"\" width=\"290\" height=\"323\" srcset=\"https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2013\/01\/012-013_Estrategias_201-2.jpg 290w, https:\/\/revistapesquisa.fapesp.br\/wp-content\/uploads\/2013\/01\/012-013_Estrategias_201-2-269x300.jpg 269w\" sizes=\"auto, (max-width: 290px) 100vw, 290px\" \/><span class=\"media-credits-inline\">1 L.A. Cicero\u20022 Personal archive<\/span><p class=\"wp-caption-text\">The Nobel Laureate in Chemistry, Brian Kobilka, supported the research of Patricia Brum from USP<span class=\"media-credits\">1 L.A. Cicero\u20022 Personal archive<\/span><\/p><\/div>\n<p>The announcement of the winners of the Nobel Prize in Chemistry, awarded in October 2012 to American scientists Robert Lefkowitz of Duke University and Brian Kobilka of Stanford University was cause for celebration for one Brazilian researcher who has a productive research collaboration with Kobilka.\u00a0 Patricia Chakur Brum, professor at the School of Physical Education and Sports and researcher at the Cellular and Molecular Physiology of Exercise Laboratory at the University of S\u00e3o Paulo (USP), did post-doctoral research at Stanford between 1999 and 2001 as a member of Kobilka\u2019s group through a research grant from FAPESP.\u00a0 Between 2003 and 2007, she also received his support for her project conducted under FAPESP\u2019s Young Investigators in Emerging Centers program.\u00a0 It was Kobilka who supplied the knockout mice for the adrenergic receptors that Brum used in her research into how sympathetic nervous hyperactivity contributes to cardiac insufficiency (<em>see<\/em> Pesquisa FAPESP Issue No.<em> 79<\/em>).\u00a0 She used mice with gene inactivation of the two receptors that regulate the heart beat\u00a0 \u2013\u00a0 alpha 2a and alpha 2c adrenergic receptors.\u00a0 The knockout mice exhibited sympathetic hyperactivity similar to that seen in humans, which led to severe cardiac insufficiency and a 50% mortality rate at 7 months of age.\u00a0 \u201cBrian helped me a lot and I always visit him when I go to Stanford,\u201d says Brum who, until September 2012, was one of the coordinators in FAPESP\u2019s health sciences area.\u00a0 She is currently on sabbatical at the Norwegian University of Science and Technology.\u00a0 The Nobel Prize recognized the work with G-protein-coupled receptors, which allow the body to sense its surroundings and adapt to new circumstances.\u00a0 In 1970, Lefkowitz discovered the first receptor of this type.\u00a0 In the decade that followed, he began to search for the gene responsible for building this receptor and hired the young\u00a0 Brian Kobilka to help him.<\/p>\n","protected":false},"excerpt":{"rendered":"Brazilian collaboration in the Nobel Price in Chemistry","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[162],"tags":[],"coauthors":[93],"class_list":["post-94040","post","type-post","status-publish","format-standard","hentry","category-strategies"],"acf":[],"_links":{"self":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/94040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/comments?post=94040"}],"version-history":[{"count":0,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/posts\/94040\/revisions"}],"wp:attachment":[{"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/media?parent=94040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/categories?post=94040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/tags?post=94040"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/revistapesquisa.fapesp.br\/en\/wp-json\/wp\/v2\/coauthors?post=94040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}