Risk of exhibiting psychiatric problems increases with

the accumulation of brain lesions

Risk of exhibiting psychiatric problems increases

with the accumulation of brain lesions

In the initial stage, classified as 0 in the Braak Staging, the first lesions appear (pink areas) on the brainstem. There are no symptoms

The lesions intensify in a nucleus (arrow) on the brainstem and initiate on the cortex (circle) in stages 1 and 2. The risk of depression, anxiety, and restlessness increase

The lesions on the brainstem worsen in stages 3 and 4.
They also advance to the cortex. The risk of depression,
anxiety, and restlessness remains high. Memory loss occurs

In stages 5 and 6, cells die (dark areas) in the brainstem and lesions cover the cortex. Memory, coordination, and perception of surroundings are compromised. Delusions and hallucinations occur