Gradual progression
The risk of exhibiting psychiatric problems
increases with the accumulation of brain lesions
In the initial stage, classified as 0 in the Braak Staging, the first lesions appear (pink areas) in the brainstem. There are no symptoms
Severity of lesions
SOURCE LEA T. GRINBERG LAB / UCSF
The lesions intensify in a nucleus (arrow) in the brainstem and begin to appear in the cortex (circle) in stages 1 and 2. The risk of depression, anxiety, and restlessness increases
The lesions in the brainstem worsen in stages 3 and 4. They also advance to the cortex. The risk of depression, anxiety, and restlessness remains high. Memory loss occurs
In stages 5 and 6, cells die (dark areas) in the brainstem and lesions cover the cortex. Memory, coordination, and perception of surroundings are compromised. Delusions and hallucinations occur
Gradual progression
The risk of exhibiting psychiatric problems
increases with the accumulation of brain lesions
Severity of lesions
In the initial stage, classified as 0 in the Braak Staging, the first lesions appear (pink areas) in the brainstem. There are no symptoms
The lesions intensify in a nucleus (arrow) in the brainstem and begin to appear in the cortex (circle) in stages 1 and 2. The risk of depression, anxiety, and restlessness increases
The lesions in the brainstem worsen in stages 3 and 4. They also advance to the cortex. The risk of depression, anxiety, and restlessness remains high. Memory loss occurs
In stages 5 and 6, cells die (dark areas) in the brainstem and lesions cover the cortex. Memory, coordination, and perception of surroundings are compromised. Delusions and hallucinations occur
SOURCE LEA T. GRINBERG LAB / UCSF