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The impacts of investing

Times of crisis bring renewed demand for returns on publicly funded research, but this ignores the fact that scientific production follows complex and interconnected pathways

CAPA_Exemplos_246In times of economic crisis, society often questions the use of public funds and wants to give priority to activities that offer visible and immediate returns.  Fields in which outcomes are more elusive or less palpable are often viewed as low-priority when it comes time for allocating funds.  When this phenomenon affects the research system, whose funding depends largely – and this varies from country to country – on the government, it is often expressed as a choice between basic and applied research, as if the two were independent concepts rather than deeply intertwined.  Investing in research that  immediately results in  new products and technologies tends to be viewed as most important because it provides tangible returns to society. Funds targeted towards basic science, however, are sometimes considered an extravagance, as we saw emphasized in 1967 when the Republican governor-elect of California, Ronald Reagan proposed, as a way to resolve budgetary problems, that taxpayers stop subsidizing “intellectual curiosity” in state university programs and courses. “We do believe that there are certain intellectual luxuries that perhaps we could do without,” said Reagan, attracting criticism from all sides.  An editorial that appeared in The Los Angeles Times responded with the following, “If a university is not a place where intellectual curiosity is to be encouraged and subsidized, then it is nothing.”

In the reality of 21st-century science, the debate calls for classifications that are far more complex than what the two categories, basic and applied science, have to offer. “The concepts of pure and applied research are useful in abstract discussions and can work in specific situations, but they do not adequately serve to categorize science,” contends Graeme Reid, a professor of science and research policy at University College London in the UK and author of the report, Why should the taxpayer fund science and research? published in 2014. In the first place, he says, the common denominator for classifying science should be “excellence,” the absence of which produces consistent results in neither basic nor applied science.

Reid cites the example of the Higher Education Funding Council for England (HEFCE), the British agency that funds and regulates university teaching and research. HEFCE allocates funds without reference to the two categories because it is the quality of the research that enables it to have an impact. The report mentions a document published in 2010 by the Council for Science and Technology associated with the British Prime Minister entitled, A vision for UK research, which states that the key role of research is its ability to ask important questions; the insistence on making a distinction between pure and applied research creates more problems and divisiveness than solutions. Reid notes that the benefits of investing in research come in several forms that go well beyond polarization between, on the one hand, the advantages of better understanding phenomena, and on the other hand, gains generated by technology development – such as university-generated start-ups capable of quickly transforming knowledge into wealth, attraction of global investments in research and development (R&D) to universities and research centers, or even the supply of highly specialized labor to companies and public agencies. “The research environment is a delicate ecosystem that delivers a multiplicity of benefits to society and the economy through complex and interconnected pathways,” Reid says.

CAPA_Equilíbrio_246Instead of distinguishing between the benefits of basic and applied science, decision-makers and institutions that support science have established new ways to classify research objectives that revolve around one key concept: the potential impact of the investment. “Impact is a very broad concept and it has several dimensions, namely, intellectual, economic and social,” said Carlos Henrique de Brito Cruz, FAPESP scientific director, in the chapter he wrote for the book University priorities and constraints (Economica, 2016), which comprises the contributions of 23 leaders of the world’s most distinguished research universities, presented at the Glion Colloquium Forum in Switzerland in June 2015. There are studies that promote benefits to society by promoting or backing public policies in nearly every sphere.  One general example is the contribution by various disciplines to understanding phenomena associated with climate.  Another of particular interest is the role the Biota-FAPESP program findings have played in legislative actions.  Established in 1999 to map the biodiversity of São Paulo State, the program has generated knowledge that has been published in scientific articles, books, atlases and maps used as references for the drafting of six government decrees and 13 environmental resolutions.

In a 2005 study funded by the Department of Research, Science and Technology, of Quebec, Canada, political scientists Benoît Godin and Christian Doré attempted to map the various types of impact generated by research and came up with a list of 11 items.  Some are well known, such as the scientific, technological and economic impacts.  Others are less studied, such as the cultural impact, which is understood as changes in habits and attitudes of individuals caused by the broader understanding of natural phenomena; or the organizational impact, in which new knowledge helps organizations improve management (see table). “Although economic impact should not be ignored, it represents only a fraction of a whole that extends into the social, cultural and organizational realms of society,” Godin and Doré explained in the study.

Science for the sake of science
A major villain in these discussions is what is referred to as research conducted for curiosity’s sake, mistakenly understood as a synonym for basic research. It is in fact science in which the scientist chooses the topic on which to work – instead of being prompted to research a particular theme or topic –, which may take on an abstract or applied character, or be a combination of both.  Although not intentionally, this path has already led to remarkable contributions in the field of lasers, atomic physics, and biotechnology. One classic case occurred in 1983 when two teams of researchers in different countries discovered that a retrovirus, later named HIV, was the cause of a recently-discovered disease: acquired immunodeficiency syndrome (AIDS).  The US team led by Robert Gallo and the French team led by Luc Montagnier obtained success thanks to years of retrovirus research driven by the curiosity of scientists, since no one could have imagined what relevance it could possibly have had for human health (see more examples).

In 1967, California governor Ronald Reagan faced protests against his plan to cut $64 million from state university budgets: in his view, funding “intellectual curiosity” was unnecessary

Bettmann / Getty Images In 1967, California governor Ronald Reagan faced protests against his plan to cut $64 million from state university budgets: in his view, funding “intellectual curiosity” was unnecessaryBettmann / Getty Images

Research that has an intellectual impact can also have an economic or social impact, but part of it will serve simply to expand the frontiers of knowledge, with no immediate tangible return. “There is not always an endpoint to be reached through basic research,” said biochemist Stephen Buratowski, a Harvard University professor, in an interview on the Harvard Medical School website.  His laboratory is currently studying the mechanisms of gene expression in eukaryotes. “Many of the subjects studied on the basis of a scientist’s curiosity are attempting to answer fundamental questions about biology.  Their understanding allows us to move forward and face actual clinical problems.”

An example of a new category of knowledge production strongly based on curiosity-driven research is what is known as transformative research, which involves ideas and discoveries that have the potential to radically change our understanding of scientific concepts and create new paradigms. The term, adopted in the second half of the past decade by the National Science Foundation (NSF), the chief US government agency that supports fundamental research, and by the UK’s Engineering and Physical Sciences Research Council (EPSRC), defines not only research that involves creativity and high risk, but also research that has the potential to lead to radically new technologies – along with the possibility of tremendous returns.  But in order to achieve these results, we need to consider that truly revolutionary ideas often take a long time to develop and possibly require substantial investments, and in the end, they still might not give us the desired results.  That is just how science is.

Trouble understanding these limitations of science frequently causes tension. In February 2016, the US House of Representatives approved a bill proposing changes to the NSF process of project evaluation. The bill, awaiting Senate approval, requires that all research projects presented to the NSF be accompanied by a justification that describes not only how the project “promotes the progress of science in the United States” but also how it serves “national interests.”  “Many of the criteria mentioned for determining whether a project is in the national interest do not apply to basic science,” said John Holdren, director of the White House Office of Science and Technology, in proposing a veto of the law if it passes.  “The authors of the law are questioning whether research will increase economic competitiveness, improve health and well-being and strengthen national defense.  That is the concern of applied research.  Is it possible that they do not understand that basic research involves the search for scientific understanding, without anticipating any particular benefit?” he asked.  This type of pressure in Congress is nothing new to the NSF. In 2013, the agency suspended the annual selection of projects in political science after Congress passed a law preventing the funding of research studies in this field if they could not be guaranteed to benefit national security or have some economic interest.  In budget negotiations, Republican Senator Tom Coburn referred to this as a “waste of federal funds on political science projects.”

CAPA_Divisão_246Knowledge and development
Discussions of public funding of research have been around since several countries decided to set up national systems for establishing science and technology policy.  This occurred after World War II, when the application of a series of scientific developments, like radar and plastic, and expansion of nutrition science had a tremendous impact, solidifying the perception that knowledge leads to development and justifying public funding.  The model establishing that it is up to the State to support basic and applied research was designed by American engineer Vannevar Bush, who headed up the US Office of Scientific Research and Development (OSRD), the US government agency through which nearly all R&D efforts were carried out during the war.  By government order, in 1945, Bush wrote a document entitled Science, the endless frontier in which he proposed that basic research be carried out without thought of practical ends.  The resulting general knowledge would provide the means to address a large number of important practical problems, even if it did not provide complete specific answers to any one of them – it would be up to applied research to provide the solutions. “The simplest and most effective way for the government to strengthen corporate research is by supporting basic research and developing scientific talent,” Bush wrote.

In an article published in the journal Revista Brasileira de Inovação in 2014, Carlos Henrique de Brito Cruz recalls that at the time, Bush did not think the US was producing a large enough volume of basic research, so much so that many applications developed in the US were based on fundamental knowledge coming out of European universities. The reactions provoked by the report in the United States were striking, as Brito Cruz wrote. “The New York Times criticized him for thinking the report proposed too little government involvement in support to research; the Wall Street Journal criticized him, advocating that industry could do everything proposed as long as it received further tax breaks via incentives.  And Budget Director Harold Smith found defense of public-funded research freedom inappropriate. He facetiously suggested that the report change its title to ‘Science: the never-ending expense’.”

“Bush advocated research freedom and investment in science as disconnected from any type of interest in applications,” says political scientist Elizabeth Balbachevsky of the School of  Philosophy, Literature and Human Sciences at the University of São Paulo (FFLCH-USP). To Bush, science was an inexhaustible source of knowledge and developments that fostered innovation. The document inspired the establishment of the NSF in 1950 and served as a guideline for establishing research funding agencies in several countries, including Brazil, that were interested in setting up their own systems of science and technology.

CAPA_Tipos_246This worked relatively well into the 1970s when the world experienced its first post-war economic crisis, affecting the major industrialized countries and dragging down many less industrialized countries.  Governments began seeking faster returns on public investments in science.  “The growing cost of research also put pressure on government and research funding budgets and added to their overriding interest in impact and short-term results,” Brito Cruz explains.  According to data from the Tufts Center for the Study of Drug Development, the cost of pre-clinical and clinical trials for new medications increased 15 times between 1970 and 2010 – and in just the past decade, that increase was 145%. At the same time, this was accompanied by attempts to expand and better understand university relationships with industry and government. “The  boom in startups that began in the 1980s made it clear to taxpayers and their representatives that the opportunity was ripe for creating wealth from knowledge at a much faster pace than ever before,” says Brito Cruz.

In 1980 came enactment of the Bayh-Dole Act, US legislation dealing with intellectual property resulting from federal government-funded research. Up to then, the government did not have a unified policy regarding patents.  Research financing agreements signed by government agencies with research institutes, companies and non-profit organizations now began to include clauses that allowed the government to relinquish ownership of inventions.  An important dimension of the new legislation consisted of expanding the categories of patentable subject matter to include knowledge and methods not directly associated with an application.

The targets of funding agencies, universities and research institutions then became university-industry partnerships, programs to support small business research and licensing of intellectual property produced by researchers. The frequency of interaction between universities and industry can be measured in terms of the relative share of industry funds used to support research.  In the United States, this percentage has fluctuated between 5% and 7% in recent years. In most countries in the Organization for Economic Development and Cooperation (OECD), private sector participation in university research funding varies from 2% to 10%. One outlier is the case of Germany where industry funds 14% of research.

Such interactions are generally two-way streets.  Industry relies on universities to share the risks of research, besides obtaining access to skilled scientists, suitable facilities and a cadre of researchers and students who can reinforce their research capacity. Universities tend to view collaboration as an opportunity to secure research funds and gain access to the science and technology challenges encountered in industry.  According to Carlos Américo Pacheco, a professor at Unicamp’s Institute of Economics, international experience shows that producing patents at universities and licensing intellectual property to companies play an important yet complementary role in business interests. “The sources of information for technology innovation in companies come more from the chain of suppliers and customers than from universities.  It is through science that companies can enable their development efforts, but they are guided more by market demands than by what the university has to offer,” he says.  In his observation, the most sophisticated and efficient way to bring together academia and the private sector has been by setting up start-up companies.  “This has strengthened certain regional clusters around universities, attracting company laboratories and investors that then become stimulating microcosms,” notes Pacheco, who served as executive secretary at the Ministry of Science and Technology from 1999 to 2002.

CAPA_Funções_246Pasteur’s quadrant
A breakthrough in the debate about the distinction between basic and applied science came with publication of the book Pasteur’s Quadrant: Basic Science and Technological Innovation (Editora Unicamp, 2005), written by Princeton University political scientist Donald Stokes, who proposed a new classification. In addition to basic research studies – best exemplified by the work of Danish physicist Niels Bohr on atomic structure and quantum physics in the first half of the 20th century – and studies of technology development – symbolized by Thomas Edison’s electric light bulb, Stokes identified another category: research that could contribute towards  advancing knowledge while offering the potential for high-impact practical use (see table). Studies conducted in France by Louis Pasteur in the field of microbiology that advanced knowledge and yielded economic benefits are an example of this category, in addition to inspiring the title of the book.

“Stokes showed that the Vannevar Bush model worked in the United States differently than in other countries because the US government invested huge sums in basic fields, but still sought to answer practical questions in the medium- and long-terms,” says Balbachevsky. “It is also the case with agencies like the National Institutes of Health (NIH) – which has more resources than the NSF – and the Department of Defense.” The United States has always maintained a dual system, concerned on the one hand with advancing knowledge, while on the other focused on potential uses – and each funding agency allocates resources to both avenues (see box). The perception that this type of investment had increased the US capacity for innovation mobilized Europe in the 1990s.  “European countries had followed the Bush model in producing high quality science, but did not develop the same interface with the manufacturing sector,” Balbachevsky adds. What we have seen in the past two decades has been an effort by Europe to create interfaces with industry.  “In the European Community, practically all of today’s programs are attempting to form networks in which governments and companies come in with a portion of the funding.”

In Horizon 2020, the European Union’s framework program for research and development, with a budget of €80 billion (close to R$285 billion) for 2014 to 2020, funds are divided into three portions.  One portion is earmarked for basic research, which funds curiosity-driven projects as well as topics that propose giving emphasis to new technologies.  The second portion is earmarked for industry research that makes funds and credit available to small, medium-sized and large companies, including programs whose return is considered high-risk. And finally, the third portion is earmarked for projects that attempt to address “challenges to society” in the form of interdisciplinary topics such as population aging, energy efficiency and food security.

The notion of challenges to society has become ubiquitous in research budgets of many countries, according to a report published in October 2015 by a group of researchers at the Science Policy Research Unit of the University of Sussex.  The report, which compared public investment in R&D by the Nordic countries (Sweden, Norway, Denmark and Finland), with some of the BRICs (Brazil, India and China) and the United States, showed that this last category has gained emphasis in the strategies of all the nations studied, with investments made in fields such as energy, climate and health.  The outlier, according to the report, is the United States, where government R&D allocations are strongly targeted towards defense (53% of the total in 2013), with health ranked second (24.3% of the total). The study concludes that there is no standard involving the ideal portion of investment to be dedicated to basic and applied research.  The trend among Nordic countries is to spend close to 40% of public funds on basic research.  In China and India, however, that proportion is much lower, at around 20% to 25% (see box). The study found no consolidated figures about the breakdown of investments in Brazil.

CAPA_Quadrante_246The entrepreneurial state
In the final analysis, should the government invest in research or not? To Italian economist Mariana Mazzucato, a professor at the University of Sussex, public funding of science plays a crucial role in producing knowledge, especially when this process involves high costs and risks that companies tend to avoid.  This is one of the taglines of her book, The Entrepreneurial State (Companhia das Letras, 2014), which states that even in highly innovative fields like pharmaceuticals, renewable energy or information technology, the private sector only comes into the game after public funding has made huge investments in research during phases in which outcomes were completely uncertain.  “In biotechnology, nanotechnology and the Internet, risk capital arrived 15 to 20 years after the most important investments had already been made using public sector funds,” Mazzucato wrote. “The State is behind most technological revolutions and extended periods of growth. That is why an ‘entrepreneurial State’ is necessary to assume risk and create a new vision, instead of just correcting market defects.”  In her talks, the author uses the example of smartphones to show that a considerable part of the technology they contain resulted from public investment, namely on the part of the US Department of Defense, when no one could ever imagine the scope of reach they would have, extending to the Internet, GPS navigational systems and touch screens.

The defense of public funding of so-called basic research has recently gained the support of the country that most invests in R&D in relative terms – the equivalent to 4% of its Gross Domestic Product – and which traditionally spends less than 20% of this total on basic science: South Korea. The strategy that paved the way towards its economic development, based on improving and lowering the cost of technologies developed by other countries, focused on basic research. In the city of Daejeon, an experiment is being carried out to detect the existence of the axion, a hypothetically elementary particle of dark matter, which makes up a good part of the Universe but is invisible.  It is a very high-risk initiative that symbolizes the country’s ambition to become a leader in basic research. If successful, the project, which is costing the country $7.6 million a year, could give South Korea the Nobel prize it has long dreamed of.  In May 2016, South Korean President Park Geun-hye announced that she would increase basic research funding by 36%. “Basic research starts with intellectual curiosity among scientists and technicians, but it could be a source of new technologies and industries,” Park said, according to the journal Nature.

Even in achieving consensus with regard to the government’s need to invest in research because of the tangible and intangible fruits it yields, there is still some discussion about how to distribute the available resources to achieve society’s expectations in the short- and long-term. The questions posed to politicians and those who manage the public system of science and technology consist of determining how much should be allocated to each research category and up to what point they should interfere, when allocating said funds, in determining what  scientists should be researching. The search for balance is important so that public research institutions can obtain high-impact results for society while also continuing to produce a consistent stock of basic knowledge.  When everyone moves to one side of the boat, it ends up sinking, said Francis Collins, NIH director, defending the importance of preserving that agency’s expenditures in basic research in a 2012 article in the journal Science. But it is also up to the researchers to keep society informed about what they are doing and what impact the knowledge they are producing is having, as Collins stated in an editorial that appeared in the journal Nature in late July 2016, celebrating the results of a European Research Council pilot study that funded 199 basic research studies.  The study showed that three fourths of the projects generated significant scientific advances and at least one quarter had an impact on the economy, society or the formulation of policies.

The usefulness of the notion of  “useful knowledge” is summarized by the conversation between US educator Abraham Flexner, founder of the Institute for Advanced Study at Princeton University, and businessman George Eastman, who popularized the use of roll film in photography, related in an article published by Flexner in Harpers magazine in 1939. Eastman was considering dedicating his vast fortune to promoting education on useful topics. Flexner asked the businessman who he considered to be the “most useful worker in science in the world.”  He quickly heard in response, Guglielmo Marconi, the Italian inventor of the radio. Flexner then surprised his listener by stating that, aside from the usefulness of the radio, the Italian’s contribution to science was practically negligible.  He explained that Marconi would not have accomplished anything were it not for the contributions of Scottish scientist James Clerk Maxwell, whose abstract equations drove investigations in the field of magnetism and electricity, and German physicist Heinrich Hertz, who later demonstrated the existence of electromagnetic waves. “Neither Maxwell nor Hertz had any concern about the utility of their work; no such thought ever entered their minds. They had no practical objective. Obviously, the inventor, in the legal sense, was Marconi, but what did Marconi invent? Merely the last technical detail, the now obsolete receiving device called a coherer, almost universally discarded,” said Flexner. Hertz and Maxwell invented nothing, but it was their apparently “useless theoretical work” that was seized upon by a clever technician to create new means of communication, utility and amusement, the educator wrote.  “Who were the fundamentally useful men?  Not Marconi, but Clerk Maxwell and Heinrich Hertz. Hertz and Maxwell were geniuses without thought of use.  Marconi was a clever inventor with no thought but use.”

References
BRITO CRUZ, C. H. “University research comes in many shapes”, p. 131-42 in University priorities and constraints, Weber, Luc E. and Duderstadt, James J. (eds.). Glion Colloquium Series. No. 9 (Economica London, Paris, Geneva, 2016).
MAZZUCATO, M. The Entrepreneurial State. São Paulo: Companhia das Letras, 2014.
BUSH, V. Science: The endless frontier. Reproduced in Revista Brasileira de Inovação. V. 13, No.. 2 July/Dec. 2014.

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